MMP7 is a target of the tumour-associated antigen EpCAM
نویسندگان
چکیده
منابع مشابه
Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM.
Epithelial cell adhesion molecule EpCAM is strongly over-expressed in a variety of carcinomas where it is involved in signalling events resulting in increased expression of target genes such as c-Myc, cyclins and others, eventually conferring cells an oncogenic phenotype. However, EpCAM is also expressed in a series of healthy epithelia, albeit generally to a far lesser extend. We have uncovere...
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15 صفحه اولMolecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM
The transduction of T cells to express chimeric T-cell antigen receptor (CAR) is an attractive strategy for adaptive immunotherapy for cancer, because the CAR can redirect the recognition specificity of T cells to tumor-associated antigens (TAAs) on the surface of target cells, thereby avoiding the limitations of HLA restriction. However, there are considerable problems with the clinical applic...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2012
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2012.00826.x